Awesome List Updates on Mar 31, 2026

20 awesome lists updated today.

🏠 Home · 🔍 Search · 🔥 Feed · 📮 Subscribe · ❤️ Sponsor

1. Awesome Malware Persistence

Collection / Windows

• PyrsistenceSniper (⭐78) - A Python-based offline Windows persistence detection tool. Point it at a KAPE dump, a Velociraptor collection, or a mounted disk image and get offline Windows persistence detection. Runs on Windows, Linux, and macOS.

2. Awesome Zig

Data & Science / Database

• zeno-core/zeno (⭐6) - High-performance embedded key-value storage engine with ART index, WAL, and sharded concurrency.

3. Awesome Cpp

Compression

• OpenZL (⭐3k) - A novel data compression framework. [BSD] website

4. Awesome Rust

Applications / Productivity

• fulsomenko/kanban (⭐85) [kanban-tui] - Terminal-based project management tool inspired by lazygit

Applications / System tools

• macpow (⭐77) - Real-time power consumption monitor TUI for Apple Silicon Macs (M1–M5+). Reads IOReport, SMC, IORegistry — no sudo required.

Applications / Text processing

• micahkepe/jsongrep (⭐504) [jsongrep] - A fast search tool for JSON, YAML, TOML, and other serialization formats with an intuitive path query syntax.

5. Free for Dev

APIs, Data, and ML

• Posthook - Schedule webhooks to fire at a future time with automatic retries, delivery tracking, and failure alerting. Free plan includes 1,000 webhooks per month.

6. Awesome Iot

Hardware

• AutoPi (⭐182) - Open-source core software for the AutoPi dongle, a Raspberry Pi-based OBD-II device for connected vehicle telematics, CAN bus data collection, and automotive IoT applications.

7. Awesome Neovim

Fuzzy Finder / Assembly

• willyelm/pulse.nvim (⭐13) - A single entrypoint for commands. Use prefixes to quickly access diagnostics, Git and more via pickers.

Colorscheme / Assembly

• 0x-ximon/acario.nvim (⭐8) - [TS][LSP][L/D][Lua] A port of the clean, high-contrast Doom Emacs Acario theme.

8. Awesome Cli Apps

Productivity / Note Taking and Lists

• kanban (⭐85) - Keyboard-driven project management tool inspired by lazygit.

9. Awesome Ai in Finance

Data Sources / Crypto Currencies

• PreReason - Pre-analyzed financial market briefings optimized for AI agent consumption. 17 briefings covering BTC on-chain, macro (Fed balance sheet, M2, Treasury yields), and cross-asset correlations. Returns regime classification, trend signals, and confidence scores in markdown.

Others / Plugins

• Hindsight - State-of-the-art long-term memory for AI agents by Vectorize. Open source, self-hostable, with integrations for LangChain, CrewAI, MCP, and more. Gives financial trading agents persistent memory across sessions.

10. Awesome Ios Books

SwiftUI

• The SwiftUI Way by Natalia Panferova

Architecture

• SwiftUI Architecture by Mohammad Azam

11. Awesome Windows

Security

• Certificate Ripper (⭐876) - A CLI tool to extract server certificates from a URL.

12. Awesome Polars

Polars plugins / Visualization

• flowview (⭐0) - A visual debugger that shows what happens at each step of your Polars DataFrame transformations in the terminal. By @guillermodotn.

Polars plugins / Miscellaneous

• immunum-polars (⭐20) - high-performance plugin for antibody segmentation and numbering, with up to 1,000,000 antibodies per second on 48-core CPU machine.

Blog posts / Miscellaneous

• Pandas vs Polars: A database speed test. Who wins? - A blog post that compares the run-time of reading a database into a dataframe using Pandas versus using Polars by Thomas Reid.

• Using Polars with Snowflake - A blog post that shows how to use Polars with Snowflake by @IndexSeek.

• Polars: A Modern DataFrame Library - An article that introduces to Polars design and its main features by @gox6.

• The Complete Guide to Polars for Data Science - A hands-on tutorial that teaches how to load, manipulate, transform and optimize data sets with Polars in Python by @norochalise. Code used is available on Github here (⭐1).

Talks and videos / Miscellaneous

• Polars: The Super Fast Dataframe Library for Python — Goodbye Pandas? - An article and a video ⏳ 19 min that explores some basic features of Polars by Frank Andrade.

13. Awesome Go

DevOps Tools / Libraries for creating HTTP middlewares

• kepfi (⭐7) - A smart alternative to rm with a recovery bin and storage tracking.

14. Awesome Mac

Utilities / Window Management

• StreamWindow - 3D window manager with intuitive views and fluid transitions.

15. Awesome Computational Biology

Compound

• DrugTargetCommons — Community platform for curating and integrating experimental bioactivity data across drugs and targets.

Protein

• UniRef — Non-redundant sequence database clustering UniProtKB entries at multiple sequence identity thresholds.

• InterPro — Protein families, domains, and functional sites database integrating 14 member databases including Pfam and PROSITE.

• Pfam — Database of protein families described by multiple sequence alignments and hidden Markov models.

• NeXtProt — Expert knowledge base on human proteins with deep functional annotation, complementary to UniProt.

Genome

• ROADMAP Epigenomics — Reference epigenome maps for 111 primary human cell types and tissues, including histone modifications, chromatin accessibility, and DNA methylation.

• FANTOM5 — Functional annotation of mammalian genome; comprehensive atlas of active enhancers, promoters, and transcription start sites across human and mouse cell types.

Disease

• Open Targets Platform — Systematic target identification and prioritization platform integrating genetics, genomics, and drug data for drug discovery.

• Human Phenotype Ontology (HPO) — Standardized vocabulary of phenotypic abnormalities in human disease, linking genes, variants, and clinical features.

• DISEASES — Gene–disease association database integrating evidence from text mining, curated databases, and experimental data.

Chemical-Protein Interaction

• Davis kinase inhibitors DB — Experimental kinase inhibitor binding affinity dataset for protein–ligand interaction research.

• Kinase Inhibitor Bioactivity Data (KIBA) — Integrated bioactivity scores for kinase inhibitors combining Ki, Kd, and IC50 measurements.

Gene Regulatory Network

• TRRUST — Manually curated database of human and mouse transcriptional regulatory interactions between transcription factors and their target genes.

• RegNetwork — Database of gene regulatory networks covering transcription factor–target gene and miRNA–gene interaction data across multiple species.

• miRBase — Reference repository for microRNA gene annotations, sequences, and experimentally validated targets.

Benchmarks & Datasets

• PK-DB — Open database of experimental pharmacokinetics (PK) and ADME data from clinical and preclinical studies.

Preprocessing Tools

• STAR (⭐2.2k) — Ultrafast universal RNA-seq aligner with support for spliced alignment and single-cell quantification via STARsolo.

• kallisto — Near-optimal RNA-seq quantification using pseudoalignment for fast transcript abundance estimation.

• Harmony (⭐631) — Fast and scalable integration of single-cell data across datasets, conditions, technologies, and species.

• Monocle3 — Single-cell trajectory analysis tool for learning developmental trajectories and ordering cells in pseudotime.

• CellChat (⭐775) — Inference and analysis of cell-cell communication ligand-receptor networks from single-cell transcriptomics data.

• SCENIC (⭐481) — Single-cell regulatory network inference and clustering linking transcription factors to co-expressed gene modules.

• DoubletFinder (⭐537) — Machine learning approach for detecting multiplet (doublet) artifacts in single-cell RNA-seq data.

Drug Response Prediction

• TGSA (⭐23) — Tumor gene set and attention-based model leveraging biological pathway knowledge for drug response prediction.

• HiDRA — Hierarchical network model incorporating gene and pathway-level information for cancer drug response prediction.

Molecular Generation

• JTVAE (⭐553) — Junction tree variational autoencoder for molecular graph generation that guarantees chemical validity via a hierarchical tree decomposition.

LLM for Biology

• MolT5 (⭐192) — Language model for molecular tasks bridging text and SMILES, enabling molecule captioning and text-driven molecule generation.

• ChatDrug (⭐158) — LLM-based conversational pipeline for drug discovery, using natural language prompts for iterative drug editing and optimization.

Protein Foundation Models / Pre-trained Embedding

• ProtTrans (⭐1.3k) — Suite of protein language models (ProtBERT, ProtT5, ProtXLNet) trained on billions of protein sequences from UniRef and BFD.

• ProGen2 (⭐695) — Protein language model trained on diverse protein families for sequence generation and fitness prediction.

• Ankh (⭐244) — Efficient protein language model optimized for downstream prediction tasks including secondary structure, localization, and function annotation.

Genomics Foundation Models / Protein Structure Prediction and Design

• DeepSEA — Deep learning framework for predicting chromatin effects of sequence alterations with single-nucleotide sensitivity across thousands of chromatin features.

• Sei (⭐112) — Sequence-to-function framework learning a genome-wide regulatory activity code from DNA sequences for variant effect prediction.

• GPN (Genomic Pre-trained Network) (⭐335) — Masked language model for DNA sequences enabling zero-shot variant effect prediction without requiring functional annotations.

16. Awesome Rest

Documentation / Symfony2

• Sourcey - Open source documentation platform for OpenAPI specs and markdown. Static HTML output.

17. Awesome Game Engine Dev

Open Source Games / C++

• 🔒 GemRB (⭐1.2k) - Open-source implementation of Bioware's Infinity Engine.

Tools / Software / AI Assistants

• 💸 Rosebud AI - Vibe coding platform for creating 3D games and interactive web apps with AI.

18. Awesome WSL

WSL Tools / Terminals

• Yaw - A cross-platform terminal that auto-detects WSL along with PowerShell, CMD, and Git Bash on Windows.

19. Free Programming Books (English, By Programming Language)

Python / Constraint Logic Programming (extended Prolog)

• Automate the Boring Stuff with Python, 3rd Edition: Practical Programming for Total Beginners - Al Sweigart (HTML) (CC BY-NC-SA)

Rust / Sinatra

• High Assurance Rust - Tiemoko Ballo (HTML) (CC BY-NC-ND)

20. Awesome Cern

Physics/mathematics analysis/simulation / Event Management

• LGC2 (⭐3): High-precision 3D least-squares adjustment for large-scale geodetic and metrology networks.

Libraries / UI

• react-openapi-generator-hook (⭐5): React library to simplify API calls using OpenApi Generator.

• Next: Mar 30, 2026