Awesome List Updates on Mar 03, 2026

11 awesome lists updated today.

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1. Awesome Game Remakes

FPS

• Barrett (⭐20) - Advanced and featureful Rise of the Triad source port for modern systems.

• Chasm-Reverse - "PanzerChasm" is a free recreation of the game "Chash: - The Rift" by "ActionForms" using the original game data (CSM.BIN file).

• idTech4A++ (Harmattan Edition) (⭐518) - DOOM III/Quake 4/Prey(2006) GLES on Android/Windows/Linux, DOOM 3 BFG/The Dark Mod/RTCW/Quake 1 2 3/GZDOOM/ETW/RealRTCW/OpenJK/SeriousSam/Skin Deep on Android.

• jfsw (⭐92) - Port of the 3D Realms game "Shadow Warrior".

• jftekwar (⭐26) - No-promises port of the Capstone Software game "TekWar".

• jfwhaven (⭐25) - No-promises port of the Capstone Software game "Witchaven".

• OpenChasm - Free software reconstruction of Chasm: The Rift game.

• Raze (⭐835) - Build engine port backed by GZDoom tech. Currently supports Duke Nukem 3D, Blood, Shadow Warrior, Redneck Rampage and Powerslave/Exhumed.

Racing

• dRally (⭐70) - Open Source Engine / Death Rally [1996]

• dethrace - Reverse engineering the 1997 game "Carmageddon"

• hi-octane202x (⭐7) - Hi-Octane with level editor using Irrlicht engine.

• tube64 (⭐19) - 64-bit vesion of DOS game Tube (Bullfrog, 1994)

Simulator

• Descent3 (⭐3k) - Descent 3 by Outrage Entertainment

Strategy

• Flame (⭐83) - Dungeon Keeper II partial recompilation with bug fixes.

• OpenDungeonsPlus (⭐16) - Open source game inspired by Dungeon Keeper - Dark, damp and dangerous...

• OpenTPW (⭐145) - An open-source re-implementation of Bullfrog's Sim Theme Park / Theme Park World (1999).

2. Awesome Bitcoin

Utilities

• BTC Airgap Bridge (⭐3) - 100% client-side tool for broadcasting signed Bitcoin transactions from air-gapped wallets.

3. Awesome Windows

Communication

• Stoat - Chat platform built with modern web tech.

IDEs

• VSCodium - A VS Code fork without all the Microsoft bloat and telemetry.

4. Awesome Claude Code

Agent Skills 🤖 / General

• Claude Scientific Skills (⭐11k) by K-Dense - "A set of ready-to-use Agent Skills for research, science, engineering, analysis, finance and writing." That's their description - modest, simple. That's how you can tell this is really one of the best skills repos on GitHub. If you've ever thought about getting a PhD... just read all of these documents instead. Also I think it IS an AI agent or something? Awesome.

5. Awesome Zig

Network & Web / Network

• zat.dev/zat - AT Protocol building blocks for zig.

6. Awesome Go

Generators

• protoc-gen-httpgo (⭐17) - Generate HTTP server and client from protobuf.

Conferences / Libraries for creating HTTP middlewares

• GopherCon China - Shanghai, China.

7. Awesome Rust

Applications

• ad-si/Woxi [woxi] - An interpreter for the Wolfram Language powered by Rust.

Applications / Web

• agrinman/tunnelto (⭐6.1k) [tunnelto] - Lets you expose your locally running web server via a public URL.

Development tools / Workflow Automation

• block/goose (⭐32k) - An open-source, local AI agent that automates engineering tasks.

• j178/prek (⭐6.7k) - A faster, dependency-free, and drop-in alternative to pre-commit, written in Rust.

Libraries / Artificial Intelligence

• raphaelmansuy/edgequake (⭐1.3k) - A high-performance Graph-RAG framework that transforms documents into intelligent knowledge graphs.

8. Awesome Mac

Browsers / Audio Record and Process

• Tabbit - An AI-native browser that understands your context, chats with webpages, and automates tasks.

Utilities / Cleanup and Uninstall

• ClearDisk (⭐39) - Visualize and clean developer caches (Xcode, node_modules, CocoaPods, SPM) to reclaim disk space on macOS.

Utilities / Window Management

• Convoker (⭐3) - Type an app name, press Enter, all its windows come to you.

QuickLook Plugins / System Related Tools

• FluxMarkdown (⭐21) - Quick Look extension for instant Markdown previews in Finder with Mermaid, KaTeX, GFM, TOC, and charts.

9. Awesome Computational Biology

scRNA

• CZ CELLxGENE — Single-cell dataset repository and interactive explorer from the Chan Zuckerberg Initiative.

• Human Cell Atlas — Open global atlas of all cells in the human body.

Compound

• HMDB (Human Metabolome Database) — Comprehensive database of small molecule metabolites found in the human body.

• DrugCentral — Online drug compendium with drug mode of action and indication information.

Protein

• SAbDab — Structural Antibody Database containing all antibody structures in the PDB.

• OADB (Observed Antibody Space Database) — Database of antibody sequences from immune repertoire sequencing.

Genome

• ENCODE — Encyclopedia of DNA Elements; regulatory and functional genomic elements across the genome.

• Ensembl — Genome browser and annotation database for vertebrate and other eukaryotic genomes.

• gnomAD — Genome Aggregation Database; genetic variation from large-scale sequencing projects.

• Rfam — Database of RNA families with sequence alignments and consensus structures.

Disease

• DisGeNET — Database of gene-disease associations integrating expert-curated and GWAS data.

• OMIM (Online Mendelian Inheritance in Man) — Comprehensive database of human genes and genetic disorders.

Protein-Protein Interaction

• IntAct — Open-source molecular interaction database and analysis system from EMBL-EBI.

Benchmarks & Datasets

• BindingDB Curated Sets — Curated binding affinity datasets for protein–ligand interaction benchmarking.

• Cancer Therapeutics Response Portal (CTRP) — Drug sensitivity profiles across ~900 cancer cell lines for >400 compounds.

• GuacaMol (⭐500) — Benchmark suite for generative molecular design models.

• MOSES (⭐957) — Benchmarking platform for molecular generation models.

• Therapeutics Data Commons (TDC) — Unified benchmark suite covering ADMET, drug-target interaction, drug response, and more.

Preprocessing Tools

• Biopython — Collection of Python tools for biological computation including sequence analysis, structure parsing, and database access.

• DeepChem (⭐6.6k) — Deep learning library for drug discovery, quantum chemistry, and materials science.

• scvi-tools — Probabilistic models for single-cell omics data analysis.

• CellTypist (⭐457) — Automated cell type annotation for scRNA-seq.

• GROMACS — Molecular dynamics simulation package for biochemical molecules.

• MDAnalysis — Python library for analyzing and altering molecular dynamics simulation trajectories.

• OpenMM — High-performance toolkit for molecular simulation and GPU-accelerated MD.

Molecular Generation

• REINVENT (⭐370) — Reinforcement learning for de novo drug design.

• MolGPT (⭐169) — Transformer-based model for molecular generation.

• Molecular Transformer (⭐413) — Sequence-to-sequence model for retrosynthesis prediction.

• TargetDiff (⭐323) — 3D equivariant diffusion model for structure-based drug design.

LLM for Biology

• ClawBio (⭐106) — Bioinformatics-native AI agent skill library with local-first pharmacogenomics, ancestry PCA, semantic similarity, nutrigenomics, and metagenomics skills.

Single-cell Foundation Models / Transcriptomics Foundation Models

• Geneformer — Context-aware, attention-based deep learning model pretrained on a large corpus of single-cell transcriptomes.

• scBERT (⭐347) — BERT-based foundation model pretrained on large-scale scRNA-seq data for cell type annotation.

• CellPLM (⭐101) — Cell pre-trained language model with inter-cell transformer architecture for diverse single-cell analysis tasks.

Single-cell Foundation Models / Spatial Foundation Models

• GigaPath (⭐578) — Slide-level digital pathology foundation model pretrained on 1.3 billion pathology image tokens from whole-slide images.

• UNI (⭐681) — General-purpose self-supervised pathology foundation model trained on 100K+ whole-slide images for diverse computational pathology tasks.

• CONCH (⭐472) — Vision-language foundation model for computational pathology trained with contrastive captioning on pathology image–text pairs.

• Phikon — ViT-based pathology foundation model pretrained with iBOT self-supervision on TCGA whole-slide images.

Single-cell Foundation Models / Multi-Omics Foundation Models

• scMulan (⭐62) — Single-cell multi-omic language model pretrained on ~10M cells spanning transcriptomics, epigenomics, and proteomics for cross-omics transfer tasks.

• totalVI (⭐1.6k) — Probabilistic framework for joint analysis of paired scRNA-seq and protein (CITE-seq) data enabling multi-modal cell state representation across single-cell datasets.

• MultiVI (⭐1.6k) — Multi-modal variational autoencoder for integrating paired and unpaired single-cell RNA-seq and ATAC-seq measurements into a unified latent space.

• MIRA (⭐67) — Probabilistic multimodal topic model jointly modeling single-cell transcriptomics and chromatin accessibility for regulatory network inference.

• GLUE (⭐455) — Graph-Linked Unified Embedding framework for unpaired single-cell multi-omics data integration across RNA, ATAC, methylation, and protein modalities.

• BABEL (⭐47) — Cross-modality translation model enabling prediction between scRNA-seq and scATAC-seq profiles without requiring paired single-cell measurements.

• Multigrate (⭐31) — Asymmetric multi-omics variational autoencoder for integrating single-cell data across RNA, ATAC, and protein modalities with missing-modality support.

• MOFA+ (⭐384) — Multi-Omics Factor Analysis framework identifying shared axes of variation across bulk and single-cell datasets including RNA, ATAC, proteomics, methylation, and copy number.

• GeneCompass (⭐111) — Large-scale foundation model integrating DNA regulatory sequences and single-cell transcriptomics from 120M+ cells across multiple species for gene regulation prediction.

• UnitedNet (⭐52) — Interpretable multi-task deep neural network for single-cell multi-omics integration spanning transcriptomics, chromatin accessibility, and proteomics.

• SpatialGlue — Graph attention network for spatial multi-omics integration jointly embedding spatial transcriptomics with chromatin accessibility or proteomics.

• MIDAS (⭐62) — Mosaic integration and differential accessibility model for single-cell multi-omics data that handles arbitrary missing-modality combinations across transcriptomics, chromatin accessibility, and proteomics.

Single-cell Foundation Models / Domain Alignment

• scArches (⭐399) — Transfer learning framework for mapping new single-cell datasets onto pre-trained reference atlases across batches, conditions, and modalities.

• TOSICA — Transformer-based framework for one-stop interpretable cell-type annotation supporting cross-dataset and cross-species transfer.

Protein Foundation Models / Protein Structure Prediction and Design

• AlphaFold3 (⭐7.7k) — Predicts structures of proteins, nucleic acids, small molecules, and their complexes.

• Boltz-1 (⭐3.8k) — Open-source all-atom biomolecular structure prediction model for proteins, nucleic acids, small molecules, and their complexes achieving AlphaFold3-level accuracy.

• Chai-1 (⭐1.9k) — Unified molecular structure prediction model covering proteins, nucleic acids, small molecules, and complexes.

• ESM3 (⭐2.3k) — Multimodal protein language model that jointly reasons over sequence, structure, and function for generative protein design and engineering.

• ESMFold (⭐4k) — Fast protein structure prediction using language model embeddings.

• RFdiffusion (⭐2.8k) — Generative model for protein backbone design using diffusion.

• ProteinMPNN (⭐1.6k) — Deep learning model for protein sequence design given backbone structure.

• OmegaFold (⭐613) — High-resolution de novo protein structure prediction from sequence.

• RoseTTAFold (⭐2.2k) — Three-track neural network for protein structure prediction.

Multi-Modal Foundation Models / Protein Structure Prediction and Design

• CHIEF (⭐688) — Clinical Histopathology Imaging Evaluation Foundation model integrating histology images and clinical context for pan-cancer analysis.

• BiomedCLIP — CLIP-based vision-language foundation model for biomedical images and text trained on PubMed figure–caption pairs.

Genomics Foundation Models / Protein Structure Prediction and Design

• Nucleotide Transformer (⭐831) — Foundation model for genomic sequences across multiple species.

• DNABERT (⭐744) — Pre-trained bidirectional encoder for DNA sequence analysis.

• DNABERT-2 (⭐460) — Improved genome foundation model with efficient tokenization.

• Enformer (⭐15k) — Transformer model predicting gene expression from DNA sequence.

• Basenji (⭐466) — Sequential regulatory activity prediction from DNA sequences.

• Caduceus (⭐226) — Bidirectional equivariant long-range DNA sequence model based on Mamba.

• Evo (⭐1.5k) — Long-context genomic foundation model (up to 1M tokens).

• HyenaDNA (⭐764) — Long-range genomic foundation model handling sequences up to 1M tokens with sub-quadratic attention.

10. Free for Dev

APIs, Data, and ML

• Compare JSON - An online tool for comparing differences between two JSON data structures, helping you quickly locate the differences in JSON data.

• HS Ping - A multi-country HS (Harmonized System) and HTS (Harmonized Tariff System) code lookup API, with a free plan offering 100 lookups/day.

Monitoring

• FlareWarden - Uptime, content, dependency, and SSL monitoring with multi-region verification and status pages. Free plan includes 15 monitors, 5-minute checks, and 90 days of history.

Generative AI

• Lumenfall.ai - AI media gateway providing unified access to leading image generation models via an OpenAI-compatible API. The platform itself is free to use with zero markup and no subscription fee. Inference costs for most models are billed at provider price, but FLUX.1 [schnell] FP8 is offered free forever with unlimited usage for registered users. Built-in failover and provider resilience included.

Miscellaneous

• SYNCDATE - Two-way Google Calendar sync. Free tier: 2 accounts, unlimited events.

11. Awesome Terraform

Tools / Community providers

• ReleaseRun Terraform Provider Matrix - Free browser tool to check Terraform provider version compatibility across Terraform and OpenTofu versions.

• terraform-ai-skills (⭐1) - AI-powered skill for GitHub Copilot, Claude, and ChatGPT that automates bulk Terraform module management — provider upgrades, workflow standardization, and releases across 10–200+ repositories on AWS, GCP, Azure, and DigitalOcean.

• Next: Mar 02, 2026