Awesome List Updates on Apr 06 - Apr 12, 2026

24 awesome lists updated this week.

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1. Awesome Windows

Security

• Certificate Ripper (⭐876) - A CLI tool to extract server certificates from a URL.

2. Awesome Computational Biology

Compound

• DrugTargetCommons — Community platform for curating and integrating experimental bioactivity data across drugs and targets.

Protein

• UniRef — Non-redundant sequence database clustering UniProtKB entries at multiple sequence identity thresholds.

• InterPro — Protein families, domains, and functional sites database integrating 14 member databases including Pfam and PROSITE.

• Pfam — Database of protein families described by multiple sequence alignments and hidden Markov models.

• NeXtProt — Expert knowledge base on human proteins with deep functional annotation, complementary to UniProt.

Genome

• ROADMAP Epigenomics — Reference epigenome maps for 111 primary human cell types and tissues, including histone modifications, chromatin accessibility, and DNA methylation.

• FANTOM5 — Functional annotation of mammalian genome; comprehensive atlas of active enhancers, promoters, and transcription start sites across human and mouse cell types.

Disease

• Open Targets Platform — Systematic target identification and prioritization platform integrating genetics, genomics, and drug data for drug discovery.

• Human Phenotype Ontology (HPO) — Standardized vocabulary of phenotypic abnormalities in human disease, linking genes, variants, and clinical features.

• DISEASES — Gene–disease association database integrating evidence from text mining, curated databases, and experimental data.

Chemical-Protein Interaction

• Davis kinase inhibitors DB — Experimental kinase inhibitor binding affinity dataset for protein–ligand interaction research.

• Kinase Inhibitor Bioactivity Data (KIBA) — Integrated bioactivity scores for kinase inhibitors combining Ki, Kd, and IC50 measurements.

Gene Regulatory Network

• TRRUST — Manually curated database of human and mouse transcriptional regulatory interactions between transcription factors and their target genes.

• RegNetwork — Database of gene regulatory networks covering transcription factor–target gene and miRNA–gene interaction data across multiple species.

• miRBase — Reference repository for microRNA gene annotations, sequences, and experimentally validated targets.

Benchmarks & Datasets

• PK-DB — Open database of experimental pharmacokinetics (PK) and ADME data from clinical and preclinical studies.

Preprocessing Tools

• STAR (⭐2.2k) — Ultrafast universal RNA-seq aligner with support for spliced alignment and single-cell quantification via STARsolo.

• kallisto — Near-optimal RNA-seq quantification using pseudoalignment for fast transcript abundance estimation.

• Harmony (⭐631) — Fast and scalable integration of single-cell data across datasets, conditions, technologies, and species.

• Monocle3 — Single-cell trajectory analysis tool for learning developmental trajectories and ordering cells in pseudotime.

• CellChat (⭐775) — Inference and analysis of cell-cell communication ligand-receptor networks from single-cell transcriptomics data.

• SCENIC (⭐481) — Single-cell regulatory network inference and clustering linking transcription factors to co-expressed gene modules.

• DoubletFinder (⭐537) — Machine learning approach for detecting multiplet (doublet) artifacts in single-cell RNA-seq data.

Drug Response Prediction

• TGSA (⭐23) — Tumor gene set and attention-based model leveraging biological pathway knowledge for drug response prediction.

• HiDRA — Hierarchical network model incorporating gene and pathway-level information for cancer drug response prediction.

Molecular Generation

• JTVAE (⭐553) — Junction tree variational autoencoder for molecular graph generation that guarantees chemical validity via a hierarchical tree decomposition.

LLM for Biology

• MolT5 (⭐192) — Language model for molecular tasks bridging text and SMILES, enabling molecule captioning and text-driven molecule generation.

• ChatDrug (⭐158) — LLM-based conversational pipeline for drug discovery, using natural language prompts for iterative drug editing and optimization.

Protein Foundation Models / Pre-trained Embedding

• ProtTrans (⭐1.3k) — Suite of protein language models (ProtBERT, ProtT5, ProtXLNet) trained on billions of protein sequences from UniRef and BFD.

• ProGen2 (⭐695) — Protein language model trained on diverse protein families for sequence generation and fitness prediction.

• Ankh (⭐244) — Efficient protein language model optimized for downstream prediction tasks including secondary structure, localization, and function annotation.

Genomics Foundation Models / Protein Structure Prediction and Design

• DeepSEA — Deep learning framework for predicting chromatin effects of sequence alterations with single-nucleotide sensitivity across thousands of chromatin features.

• Sei (⭐112) — Sequence-to-function framework learning a genome-wide regulatory activity code from DNA sequences for variant effect prediction.

• GPN (Genomic Pre-trained Network) (⭐335) — Masked language model for DNA sequences enabling zero-shot variant effect prediction without requiring functional annotations.

3. Awesome Rest

Documentation / Symfony2

• Sourcey - Open source documentation platform for OpenAPI specs and markdown. Static HTML output.

4. Awesome Game Engine Dev

Tools / Software / AI Assistants

• 💸 Rosebud AI - Vibe coding platform for creating 3D games and interactive web apps with AI.

Open Source Games / C++

• 🔒 GemRB (⭐1.2k) - Open-source implementation of Bioware's Infinity Engine.

5. Awesome WSL

WSL Tools / Terminals

• Yaw - A cross-platform terminal that auto-detects WSL along with PowerShell, CMD, and Git Bash on Windows.

6. Free Programming Books (English, By Programming Language)

Python / Constraint Logic Programming (extended Prolog)

• Automate the Boring Stuff with Python, 3rd Edition: Practical Programming for Total Beginners - Al Sweigart (HTML) (CC BY-NC-SA)

Rust / Sinatra

• High Assurance Rust - Tiemoko Ballo (HTML) (CC BY-NC-ND)

7. Awesome Cern

Physics/mathematics analysis/simulation / Event Management

• LGC2 (⭐3): High-precision 3D least-squares adjustment for large-scale geodetic and metrology networks.

Libraries / UI

• react-openapi-generator-hook (⭐5): React library to simplify API calls using OpenApi Generator.

8. Awesome Go

Data Structures / Maps

• lrita/cmap (⭐101) — a thread-safe concurrent map for go ☆101

9. Awesome Polars

Official documentation

• Documentation for Rust API - Official API Reference for Rust.

• Documentation for R API - Official API Reference for R.

Polars plugins / Data Manipulation

• pl-compare - Compare Dataframes to find difference in the schemas, rows and column values by @concur1.

Polars plugins / Time series / Datetime

• functime (⭐1.2k) - Machine learning Python package built on Polars for time-series predictions by @functime-org. According to the developpers, it's the world's fastest and most feature-full machine learning forecasting library !

Polars plugins / General utilities / Performance

• polars-map (⭐4) - Polars extension that provids a Map extension type and functions by @hafaio.

Polars plugins / Statistics / Analytics

• polars_kde (⭐2) - Polars plugin for kernel density estimation by @schemaitat.

Polars plugins / Miscellaneous

• immunum-polars (⭐20) - high-performance plugin for antibody segmentation and numbering, with up to 1,000,000 antibodies per second on 48-core CPU machine.

Rust / Miscellaneous

• polars for Rust (⭐38k) - Rust polars crate to use polars DataFrame with Rust.

Tutorials & workshops / Miscellaneous

• Rust Polars: Unlocking High-Performance Data Analysis — Part 1 - First part of an article that explores the world of Rust’s Polars and explain some basic concepts of Polars such as Series by @wiseaidev. Code used is available on Github here (⭐457).

• Fast String Processing with Polars — Scam Emails Dataset - A tutorial using Polars to implement a text processing pipeline process by @AntonsRuberts. Code used is available on Github here (⭐69).

• Data Pipelines with Polars: Step-by-Step Guide - A tutorial that explains how to build data pipelines with Polars by @AntonsRuberts. Code used is available on Github here (⭐69).

• Introduction course that introduces the concept of DataFrame (⭐0) with Polars and Python. It also proposes some corrected exercices by @TLouf.

Blog posts / Miscellaneous

• Why Polars uses less memory than Pandas - A blog post by Itamar Turner-Trauring detailing some techniques to opptimize Pandas memory usage and see how Polars can provide an answer in some cases.

• 7 Easy Steps To Switch From Pandas to Lightning Fast Polars And Never Return - A cheat sheet blog post of the most common Pandas operations translated into Polars by @BexTuychiev.

• Pandas vs Polars: A database speed test. Who wins? - A blog post that compares the run-time of reading a database into a dataframe using Pandas versus using Polars by Thomas Reid.

• Using Polars with Snowflake - A blog post that shows how to use Polars with Snowflake by @IndexSeek.

• Using Polars Plugins for a 14x Speed Boost with Rust - A blog post thats shows the use of Polars plugin system for Rust from some concrete examples by @ngriffiths13.

• Anatomy of a Polars Query: A Syntax Comparison of Polars vs SQL - A post that compares Polars syntax to SQL by @bfeif.

• Pandas vs. Polars — Time to Switch? - A blog post that compares Polars to Pandas in a series of 4 benchmarks performed on a csv file with 11 million rows by @daradecic.

• Polars: A Modern DataFrame Library - An article that introduces to Polars design and its main features by @gox6.

• Case Study Comparing Pandas and Polars with 1 Million Rows Data - An blog post that compares benchmarking scores with the Independent samples t-test and Welch’s t-test using Python.

• Build a Decision Tree in Polars from Scratch - A post that explains how to build a decision tree with Polars by @tocab. Code used is available on Github here (⭐6).

• The Complete Guide to Polars for Data Science - A hands-on tutorial that teaches how to load, manipulate, transform and optimize data sets with Polars in Python by @norochalise. Code used is available on Github here (⭐1).

Talks and videos / Miscellaneous

• Polars: The Super Fast Dataframe Library for Python — Goodbye Pandas? - An article and a video ⏳ 19 min that explores some basic features of Polars by Frank Andrade.

10. Awesome Python

Data Validation

• voluptuous (⭐1.8k) - A Python data validation library primarily intended for validating data from untrusted sources.

11. Awesome Preact

Contents / Libraries

• Preact In Motion (⭐32) - Light, elegant animation plugin for Preact (powered by Motion.dev and WAAPI).

12. Awesome Tmux

Plugins

• tabby (⭐25) Modern tab manager with a daemon-driven vertical sidebar, window grouping, and full mouse support.

13. Awesome Cli Apps

AI / Agents

• InkOS (⭐2.9k) - Novel-writing agent.

14. Awesome Mysql

Development

• cover_me (⭐3) - code coverage tool for mysql stored procedures and functions

15. Awesome Ai in Finance

Agents

• ProfitPlay Agent Arena (⭐4) - Open prediction market arena where AI agents compete in real-time BTC/ETH/SOL prediction games. Python and Node.js SDKs, 9 live markets, REST + WebSocket APIs.

Technical Analysis

• MarginSafe.ai - AI stock analysis platform specialized in intrinsic value and Wyckoff timing.

Research Tools / Prediction Markets

• CRNG (⭐2) - Contingency RNG, generates random numbers with real market fat tails (K=5-220) and volatility clustering. Matches 86% of real market metrics vs 14% for NumPy. Includes regime detector.

16. Awesome Datascience

Podcasts / Book Deals (Affiliated)

• Chain of Thought

17. Awesome Claude Code

Tooling 🧰 / General

• claude-devtools (⭐2.8k) by matt1398 - A well-designed desktop app that provides detailed observability into your Claude Code sessions by analyzing the session logs. Provides turn-based context data across numerous categories, compaction visualization, subagent execution trees, and custom notification triggers. Easy to install, and nice visual design.

18. Awesome Testing

Software / AI & LLM Testing

• Litmus (⭐2) - Record and replay AI agent LLM calls deterministically for testing and CI, with fault injection and reliability scoring.

19. Awesome Go

Artificial Intelligence

• otellix (⭐0) - OpenTelemetry-native LLM observability and budget guardrails for cost-constrained production environments.

Distributed Systems

• circuit (⭐2) - Circuit breaker with gradual recovery via probabilistic throttling.

• health (⭐8) - Health checker for Go services with Kubernetes probe support.

Strings

• str (⭐7) - Pipeline-first string toolkit for composing transformations.

DevOps Tools / Libraries for creating HTTP middlewares

• aws-doctor (⭐372) - Diagnose AWS costs, detect idle resources, and optimize cloud spending directly from your terminal 🩺 ☁️.

• kepfi (⭐7) - A smart alternative to rm with a recovery bin and storage tracking.

20. Awesome Mac

Terminal Apps / Databases

• Flock (⭐2) - Terminal multiplexer for running multiple Claude Code and shell sessions in one workspace.

AI Client / Other Tools

• Atomic Chat (⭐258) - Open-source AI chat client for local LLMs and cloud models with MCP and OpenAI-compatible API support.

• ClawdHome - Manage multiple isolated OpenClaw gateway instances from one control panel.

Proxy and VPN Tools / Audio Record and Process

• ClashBar - mihomo-powered menu bar proxy client.

• DashVPN - Smart-routing proxy client with support for VLESS, Shadowsocks, and HTTPS subscriptions.

Utilities / Menu Bar Tools

• Repose (⭐1) - Menu bar break timer that dims your screen and pauses during calls.

Utilities / Window Management

• StreamWindow - 3D window manager with intuitive views and fluid transitions.

Utilities / Quality of Life Improvements

• Dimly - Control brightness across mixed monitor setups from one menu bar app.

21. Awesome Mqtt

Smart Home Hardware Interfaces / Firmwares for ESP based Devices

• huABus (⭐5) - Home Assistant application (Add-on) and MQTT bridge for Huawei solar inverters (SUN2000/3000/5000).

22. Awesome Selfhosted

Software / URL Shorteners

• Kutt - Modern URL shortener with support for custom domains and custom URLs. (Demo, Source Code (⭐11k)) MIT Nodejs/Docker

23. Awesome Fiber

🛠️ Tools / 🌱 Third Party

• MUlt1mate/protoc-gen-httpgo (⭐17) - A protoc plugin that generates Fiber HTTP server and client code from proto files.

24. Awesome Terraform

Tools / Community providers

• terravision (⭐1.4k) - Generates professional cloud architecture diagrams from Terraform code using official AWS/Azure/GCP icons and design standards. Runs 100% client-side with CI/CD integration.

• Next: Mar 30 - Apr 05, 2026